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| Filing Date | Reporting Person | Amount Beneficially Owned | % of Class |
|---|---|---|---|
| 2017-11-03 | Armistice Capital Master Fund Ltd. | 768.92K | 5.60% |
| 2017-11-03 | Steven Boyd | 768.92K | 5.60% |
| 2017-11-03 | Armistice Capital, LLC | 768.92K | 5.60% |
| 2014-10-03 | Broadfin Healthcare Master Fund, Ltd. | 1.3M | 5.70% |
| 2014-10-03 | Broadfin Capital, LLC | 1.3M | 5.70% |
| 2014-10-03 | Kevin Kotler | 1.3M | 5.70% |
| 2012-07-30 | KEVIN C. TANG | 5.5M | 7.40% |
| 2012-07-30 | TANG CAPITAL MANAGEMENT, LLC | 5.5M | 7.40% |
| 2012-07-30 | TANG CAPITAL PARTNERS, LP | 5.5M | 7.40% |
| 2012-07-27 | RA Capital Healthcare Fund, L.P. | 2.68M | 3.60% |
| 2012-07-27 | Peter Kolchinsky | 4.5M | 6.10% |
| 2012-07-27 | RA Capital Management, LLC | 4.5M | 6.10% |
| 2011-02-10 | 04-3519872 | 1.89M | 5.70% |
| 2010-10-01 | Jacob Gottlieb | 1.91M | 5.74% |
| 2010-10-01 | Visium Balanced Master Fund, Ltd | 1.91M | 5.74% |
| 2010-10-01 | Visium Asset Management, LP | 1.91M | 5.74% |
| 2010-10-01 | JG Asset, LLC | 1.91M | 5.74% |
| 2010-09-28 | Samuel D. Isaly | 4.76M | 13.95% |
| 2010-09-28 | OrbiMed Advisors LLC | 4.76M | 13.95% |
| 2010-09-28 | OrbiMed Capital GP IV LLC | 4.76M | 13.95% |
| 2010-03-15 | HBM BioCapital Ltd. | 1.52M | 7.00% |
| 2010-03-15 | HBM BioCapital (EUR) L.P. | 1.52M | 7.00% |
| 2010-03-15 | HBM BioCapital (USD) L.P. | 1.52M | 7.00% |
| 2010-03-12 | VantagePoint Venture Partners IV Principals Fund, L.P. | 21277.0 | 0.10% |
| 2010-03-12 | VantagePoint Venture Partners IV (Q), L.P. | 5.84M | 26.80% |
| 2010-03-12 | VantagePoint Venture Partners IV, L.P. | 584.95K | 2.70% |
| 2010-03-12 | VantagePoint Venture Associates IV, L.L.C. | 6.46M | 29.60% |
| 2010-03-12 | Alan E. Salzman | 6.46M | 29.60% |
| 2010-03-11 | Arthur M. Pappas | 1.16M | 5.40% |
| 2010-03-11 | III, LP | 1.09M | 5.10% |
| 2010-03-11 | LP | 67867.0 | 0.30% |
| 2010-03-11 | LLC | 1.16M | 5.40% |
| Date | Stock Price | Shares Outstanding | Market Cap | Cash & Equivalents | Total Debt | Enterprise Value |
|---|---|---|---|---|---|---|
| 2017-12-31 | $1.79 | 10.28M | $18.4M | $2.2M | -$ | $16.2M |
| 2016-12-31 | $5.19 | 5.16M | $26.8M | $20.84M | -$ | $5.96M |
| 2015-12-31 | $37.12 | 4.45M | $165.33M | $46.95M | -$ | $118.38M |
| 2014-12-31 | $12.64 | 2.72M | $34.41M | $2.64M | -$ | $31.77M |
| 2013-12-31 | $24.56 | 2.28M | $56.08M | $25.95M | $17.88M | $48.01M |
| 2012-12-31 | $39.68 | 903.18K | $35.84M | $19.43M | $20.55M | $36.96M |
| 2011-12-31 | $392.96 | 584.65K | $229.74M | $65.62M | $24.33M | $188.45M |
| 2010-12-31 | $312.32 | 357.96K | $111.8M | $40.03M | -$ | $71.77M |
| 2009-12-31 | $448.64 | 23649 | $10.61M | $3.8M | $13.13M | $19.94M |
| 2008-12-31 | $448.64 | 23649 | $10.61M | $7.9M | -$ | $2.71M |
| Date | Stock Price | Shares Outstanding | Market Cap | Cash & Equivalents | Total Debt | Enterprise Value |
|---|---|---|---|---|---|---|
| 2018-03-31 | $0.31 | 22.17M | $6.95M | $8.09M | -$ | -$1.14M |
| 2017-12-31 | $1.79 | 13.19M | $23.61M | $2.2M | -$ | $21.42M |
| 2017-09-30 | $1.44 | 10.95M | $15.76M | $6.08M | -$ | $9.69M |
| 2017-06-30 | $1.62 | 10.14M | $16.42M | $11.15M | -$ | $5.27M |
| 2017-03-31 | $3.40 | 6.76M | $22.98M | $20.65M | -$ | $2.33M |
| 2016-12-31 | $5.19 | 5.31M | $27.55M | $20.84M | -$ | $6.7M |
| 2016-09-30 | $25.20 | 5.21M | $131.3M | $32.57M | -$ | $98.73M |
| 2016-06-30 | $24.72 | 5.13M | $126.79M | $28.5M | -$ | $98.29M |
| 2016-03-31 | $28.96 | 5.01M | $144.98M | $37.88M | -$ | $107.1M |
| 2015-12-31 | $37.12 | 4.99M | $185.35M | $46.95M | -$ | $138.4M |
| 2015-09-30 | $48.72 | 4.91M | $238.98M | $55.76M | -$ | $183.22M |
| 2015-06-30 | $68.96 | 4.48M | $308.75M | $35.46M | -$ | $273.29M |